Synthesis and broad-spectrum antiviral activity of some novel benzo-heterocyclic amine compounds was written by Zhang, Da-Jun;Sun, Wen-Fang;Zhong, Zhao-Jin;Gao, Rong-Mei;Yi, Hong;Li, Yu-Huan;Peng, Zong-Gen;Li, Zhuo-Rong. And the article was included in Molecules in 2014.Recommanded Product: 2942-06-5 This article mentions the following:
A series of novel unsaturated five-membered benzo-heterocyclic amine derivatives I [X = NH, O, S; Y = CH, N; R = 4-chlorobenzyl, 3-phenylallyl, 5-methylthiophene, etc.]. were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities. The biol. results showed that most of the synthesized compounds exhibited potent broad-spectrum antiviral activity. Notably, compounds I [X = S; Y = N; R = (2-methoxy-phenyl)amine] (IC50 = 3.21-5.06 渭M) and I [X = S; Y = N; R = 5-methylfuran] (IC50 = 0.71-34.87 渭M) showed potent activity towards both RNA viruses (influenza A, HCV and Cox B3 virus) and a DNA virus (HBV) at low micromolar concentrations The SAR study showed that electron-withdrawing substituents located on the aromatic or heteroaromatic ring favored antiviral activity towards RNA viruses. In the experiment, the researchers used many compounds, for example, 6-Nitrobenzothiazole (cas: 2942-06-5Recommanded Product: 2942-06-5).
6-Nitrobenzothiazole (cas: 2942-06-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 2942-06-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica