Organocatalyst-Mediated Dynamic Kinetic Enantioselective Acylation of 2-Chromanols was written by Glazier, Daniel A.;Schroeder, John M.;Liu, Jitian;Tang, Weiping. And the article was included in Advanced Synthesis & Catalysis in 2018.Synthetic Route of C15H12N2S This article mentions the following:
In this update, a catalytic method for the dynamic kinetic enantioselective acylation of 2-chromanols using benzotetramisole-derived catalysts is reported. High yields and enantiomeric excesses were obtained for a broad range of acylated 2-chromanols, which are important intermediates for the synthesis of various bioactive pharmaceuticals. The high stereoselectivity of the reaction originates from a novel cation-n interaction between the chromanol substrate and the acylated catalyst. In the experiment, the researchers used many compounds, for example, (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3Synthetic Route of C15H12N2S).
(S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Synthetic Route of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica