Nitrogen bridgehead compounds. Part 67. Preparation of novel polycyclic quaternary salts was written by Bitter, Istvan;Pete, Bela;Agai, Bela;Toke, Laszlo;Toth, Gabor;Hermecz, Istvan;Simon, Kalman;Meszaros, Zoltan;Parkanyi, Laszlo. And the article was included in Heterocycles in 1987.Computed Properties of C4H7NS This article mentions the following:
The cycloaddition reaction of (aminochloromethylene)pyridopyrimidines I (R1 = CO2Et, cyano) with 3,4-dihydroisoquinolines gave ioquinodiazaazoniaphenalene salts II (R2 = H, Me; R3 = H, OMe; X = Cl, ClO4). Similarly fused compounds were obtained from 2-thiazoline and 2-oxazoline derivatives, benzothiazole, and a benzoxazole derivative The crystal and mol. structure of II (R1 = cyano, R2 = R3 = H, X = Cl) were obtained. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Computed Properties of C4H7NS).
2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C4H7NS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica