The effect of nitrite on 14C-sulfathiazole (4-amino-N-2-thiazolyl[U14C]benzenesulfonamide) metabolism in the rat was written by Nelson, P. A.;Paulson, G. D.;Feil, V. J.. And the article was included in Xenobiotica in 1987.SDS of cas: 127-76-4 This article mentions the following:
Rats given a meal containing 613 p.p.m. of 14C-sulfathiazole excreted less 14C-activity in urine and more 14C-activity in feces as nitrite in the meal was increased (0, 10, 100, or 1000 p.p.m.). As nitrite in the meal was increased from 0 to 1000 p.p.m. the total 14C-residues in the gastrointestinal tract 6 h after dosing increased, but decreased in other tissues. High nitrite in the meal resulted in increased methanol insoluble 14C-activity in the gastrointestinal tract but had little or no effect on the methanol-insoluble activity in liver and blood. Conversion of 14C-sulfathiazole to 14C-desaminosulfathiazole in the rat was greatly increased by nitrite in the meal. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4SDS of cas: 127-76-4).
N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1).Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.SDS of cas: 127-76-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica