Solubility of several sulfanilamide compounds in water and in water-alcohol mixtures was written by Sapozhnikova, N. V.;Postovskii, I. Ya.. And the article was included in Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) in 1944.Reference of 127-76-4 This article mentions the following:
The solubilities in water of sulfanilamide, sulfaguanidine, sulfapyridine, sulfamethylthiazole, sulfathiazole, sulfamethyldiazine and their Ac derivatives were determined at 20-39掳. N’-heterocyclic derivatives have poor water solubility Heats of solution range from 9500 to 10, 600 cal./mol. All compounds, except diacetylsulfanilamide have maximum solubility in EtOH-water mixtures of 67-76% EtOH. Solubilities in water up to 100掳 are given in graphical form. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4Reference of 127-76-4).
N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Reference of 127-76-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica