Pharmacokinetics and mechanism of renal excretion of short acting sulfonamides and N4-acetylsulfonamide derivatives in man. Structural requirements of sulfonamides for active tubular secretion was written by Vree, T. B.;Hekster, Y. A.;Damsma, J. E.;Tijhuis, M.;Friesen, W. T.. And the article was included in European Journal of Clinical Pharmacology in 1981.Computed Properties of C11H11N3O3S2 This article mentions the following:
The pharmacokinetics of short acting sulfonamides and a series of N4-acetylsulfonamides was investigated. Sulfonamides with a S atom 2 at. bond distances from the N1-atom are excreted by active tubular secretion, e.g. sulfamethizole [144-82-1], sulfaethidole [94-19-9], and sulfathiazole [72-14-0]. When the S atom is replaced by an O or N, active renal excretion no longer occurs. N4-Acetylsulfonamides are excreted by active tubular secretion. The renal clearance value of the N4-acetylsulfonamides are not influenced by the substituent at the N1 position. Two groups of N4-acetylsulfonamides can be distinguished. One has a T1/2 of 4-6 h and a renal clearance value of 20-60 mL/min and the second has a T1/2 of 10-20 h and a renal clearance of <10 mL/min. N4-Acetylsulfonamides are deacetylated ∼5%. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4Computed Properties of C11H11N3O3S2).
N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C11H11N3O3S2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica