A Double-Clicking Bis-Azide Fluorogenic Dye for Bioorthogonal Self-Labeling Peptide Tags was written by Demeter, Orsolya;Fodor, Eszter A.;Kallay, Mihaly;Mezo, Gabor;Nemeth, Krisztina;Szabo, Pal T.;Kele, Peter. And the article was included in Chemistry – A European Journal in 2016.Application of 2942-06-5 This article mentions the following:
Herein, the authors give the very first example for the development of a fluorogenic mol. probe that combines the two-point binding specificity of biarsenical-based dyes with the robustness of bioorthogonal click-chem. This proof-of-principle study reports on the synthesis and fluorogenic characterization of a new, double-quenched, bis-azide fluorogenic probe suitable for bioorthogonal two-point tagging of small peptide tags by double strain-promoted azide-alkyne cycloaddition The presented probe exhibits remarkable increase in fluorescence intensity when reacted with bis-cyclooctynylated peptide sequences, which could also serve as possible self-labeling small peptide tag motifs. In the experiment, the researchers used many compounds, for example, 6-Nitrobenzothiazole (cas: 2942-06-5Application of 2942-06-5).
6-Nitrobenzothiazole (cas: 2942-06-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Application of 2942-06-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica