With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1024583-33-2,Methyl 2-bromobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.
4-(((2-Azabicyclo[4.1.0]heptane-5-yl)oxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl) The crude product of the above-mentioned oxazole, 2-bromobenzo[d]thiazolidine methyl-6-carboxylate (240 mg, 0.88 mmol) and cesium carbonate (429 mg,1.32 mmol) was dissolved in DMA (6 mL), and subjected to microwave reaction at 110 C for 40 minutes. After completion of the reaction, 100 mL of water and 30 mL of ethyl acetate were added and the mixture was separated, and the aqueous phase was extracted with ethyl acetate (30 mL¡Á2). concentrate, The residue was subjected to silica gel column chromatography ( petroleum ether: ethyl acetate = 2:1)The product was obtained in 183 mg in two-step yield: 72.9%.
1024583-33-2 Methyl 2-bromobenzo[d]thiazole-6-carboxylate 46911877, athiazole compound, is more and more widely used in various.
Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; (39 pag.)CN109575008; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica