121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Chloroacetyl chloride (2 mmol) was added drop wise to a well stirred suspension of corresponding amine (1 mmol) and TEA (3 mmol) in DMF (15 mL) at 0 C. The reaction mixture was then stirred at rt for about 3 h (monitored by TLC & LCMS for completion), and the solvent evaporated under reduced pressure. The residue was further diluted with water (20 mL) and ethyl acetate (30 mL), and the layers separated. The aqueous layer was reextracted with ethyl acetate (2 x 30 mL) and the combined organic layer was washed with brine (20 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure. The residue was purified by silica column chromatography using hexane:ethyl acetate as eluent to give corresponding 2-chloro-N-(aryl/heteroaryl)acetamides (28a-c).
The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Pedgaonkar, Ganesh S.; Sridevi, Jonnalagadda Padma; Jeankumar, Variam Ullas; Saxena, Shalini; Devi, Parthiban Brindha; Renuka, Janupally; Yogeeswari, Perumal; Sriram, Dharmarajan; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 613 – 627;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica