With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185613-91-6,4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine,as a common compound, the synthetic route is as follows.
(Benzo [d] [1,3] dioxol-5-yl) thiazol-2-amine (2)(1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) were dissolved in THF (15 ml) and reacted at room temperature for 1 hour under a nitrogen stream. Benzyl bromide (1.17 g, 6.82 mmol) was then slowly added dropwise at room temperature and allowed to react for 10 minutes. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, dissolved in ethyl acetate, and saturated NaHCO 3 solution was added thereto. The ethyl acetate layer was separated, dried over anhydrous Na2SO4 and then purified by column chromatography (Ethyl acetate: Hexane = 1: 5) to obtain Compound 1a. Yield: 21.2%
As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.
Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica