2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-Chlorobenzothiazole(169 mg, 1 mmol) and EtOH (5 ml), and 3-fluoro-4-hydroxyaniline (127 mg, 1 mmol) was dissolved in and p-TsOH*H2O (30.4 mg, 0.1 mmol) was added and the mixture was stirred for 4 hours at 80 ¡ã C. After checking the completion of the reaction, then cooled at room temperature, then evaporated under reducedpressure to remove the solvent. The concentrated residue was extracted with ethyl acetate (5 ml) and water (3 x 3ml). The extractedorganic layer was filtered and then dried over anhydrous magnesium sulfate, the reduced pressure of the filtrate was evaporated,and purified by column chromatography, and diluted with an equal volume of HCl solution and dried. As a result, 4-(benzo[d]thiazol-2-ylamino)-2-fluorophenol was obtained (222 mg, 75percent yield).
The synthetic route of 2516-40-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Gyeonggi Science & Technology Agency; Koo, Jin Moh; Jung, Kwi Wan; Kim, Soo Mi; Park, Jong Hyun; Noh, Jae Sung; Lee, Jung Heon; Park, Sun Min; Jung, Dae Yeon; Lee, Kwang Nyung; Choe, Joo Hyung; (36 pag.)KR101659952; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica