Related Products of 3034-22-8, An article , which mentions 3034-22-8, molecular formula is C3H3BrN2S. The compound – 5-Bromothiazol-2-amine played an important role in people’s production and life.
The present invention relates to compounds of formula (I) STR1 wherein X is a 5-or 6-membered C-linked heteroaromatic ring containing 1 to 4 nitrogen atoms and optionally containing in the ring one oxygen or sulphur atom; Y is a group of the formula–(CH 2) n NR 6 R. sup.7 or a methylene-or ethylene-linked imidazolyl group; Z is hydrogen or C 1-4 alkyl optionally substituted by a hydroxy group; R. sup.1, R. sup.2, R 3, R 4, R. sup.5, R 9a and R 9b are a variety of substituents; R 6 is hydrogen, C 1-6 akyl, C. sub.3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, or C 2-4 akyl substituted by C 1-4 alkoxy or hydroxy, R. sup.7 is hydrogen, C. sub.1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, or C 2-4 alkyl substituted by one or two substituents selected from C 1-4 alkoxy, hydroxy or a 4-, 5-or 6-membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R 6 and R 7, together with the nitrogen atom to which they are attached, form a saturated or partially saturated heterocyclic ring or a non-aromatic azabicyclic ring system; and n is zero, 1 or 2; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherapeutic neuralgia.
The present invention relates to compounds of formula (I) STR1 wherein X is a 5-or 6-membered C-linked heteroaromatic ring containing 1 to 4 nitrogen atoms and optionally containing in the ring one oxygen or sulphur atom; Y is a group of the formula–(CH 2) n NR 6 R. sup.7 or a methylene-or ethylene-linked imidazolyl group; Z is hydrogen or C 1-4 alkyl optionally substituted by a hydroxy group; R. sup.1, R. sup.2, R 3, R 4, R. sup.5, R 9a and R 9b are a variety of substituents; R 6 is hydrogen, C 1-6 akyl, C. sub.3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, or C 2-4 akyl substituted by C 1-4 alkoxy or hydroxy, R. sup.7 is hydrogen, C. sub.1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, or C 2-4 alkyl substituted by one or two substituents selected from C 1-4 alkoxy, hydroxy or a 4-, 5-or 6-membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R 6 and R 7, together with the nitrogen atom to which they are attached, form a saturated or partially saturated heterocyclic ring or a non-aromatic azabicyclic ring system; and n is zero, 1 or 2; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherapeutic neuralgia.
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Reference£º
Thiazole | C3H6182NS – PubChem,
Thiazole | chemical compound | Britannica