The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.566169-93-5, Name is 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol, molecular formula is C14H12N2OS. In a Article£¬once mentioned of 566169-93-5, Quality Control of: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
A series of fluoro-pegylated (FPEG) 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives were synthesized and evaluated as novel beta-amyloid (Abeta) imaging probes for PET. They displayed binding affinities for Abeta1-42 aggregates that varied from 2.7 to 101.6 nM. Seven ligands with high affinity were selected for 18F labeling. In vitro autoradiography results confirmed the high affinity of these radiotracers. In vivo biodistribution experiments in normal mice indicated that the radiotracers with a short FPEG chain (n = 1) displayed high initial uptake into and rapid washout from the brain. One of the 2-pyridinylbenzoxazole derivatives, [18F]-5-(5-(2-fluoroethoxy)benzo[d]oxazol-2-yl)-N- methylpyridin-2-amine ([18F]32) (Ki = 8.0 ¡À 3.2 nM) displayed a brain2min/brain60min ratio of 4.66, which is highly desirable for Abeta imaging agents. Target specific binding of [ 18F]32 to Abeta plaques was validated by ex vivo autoradiographic experiment with transgenic model mouse. Overall, [18F]32 is a promising Abeta imaging agent for PET and merits further evaluation in human subjects.
A series of fluoro-pegylated (FPEG) 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives were synthesized and evaluated as novel beta-amyloid (Abeta) imaging probes for PET. They displayed binding affinities for Abeta1-42 aggregates that varied from 2.7 to 101.6 nM. Seven ligands with high affinity were selected for 18F labeling. In vitro autoradiography results confirmed the high affinity of these radiotracers. In vivo biodistribution experiments in normal mice indicated that the radiotracers with a short FPEG chain (n = 1) displayed high initial uptake into and rapid washout from the brain. One of the 2-pyridinylbenzoxazole derivatives, [18F]-5-(5-(2-fluoroethoxy)benzo[d]oxazol-2-yl)-N- methylpyridin-2-amine ([18F]32) (Ki = 8.0 ¡À 3.2 nM) displayed a brain2min/brain60min ratio of 4.66, which is highly desirable for Abeta imaging agents. Target specific binding of [ 18F]32 to Abeta plaques was validated by ex vivo autoradiographic experiment with transgenic model mouse. Overall, [18F]32 is a promising Abeta imaging agent for PET and merits further evaluation in human subjects.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol, you can also check out more blogs about566169-93-5
Reference£º
Thiazole | C3H487NS – PubChem,
Thiazole | chemical compound | Britannica