With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-83-1,2-Chlorobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.
80945-83-1, Step 1 : 2-(4-(2-chloro-4-((5-cvclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-4- hvdroxypiperidin-1-yl)benzo[d]thiazole-6-carbonitrile To a sealed tube equipped with a magnetic stirring bar, 4-(2-chloro-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)piperidin-4-ol hydrochloride (General synthesis 4, step 2) (100 mg, 0.19 mmol), 2-chlorobenzo[d]thiazole-6-carbonitrile (54.1 mg, 0.23 mmol), potassium carbonate (234 mg, 3.8 mmol) and DMF ( 2 mL) were added. The tube was sealed and the mixture was heated at 80 ¡ãC for 40 minutes. Water (20 mL) was added and the resulting mixture was extracted with EtOAc (50 mL X 3), the combined organic phases were washed with brine (20 mL), dried over Na2S04, filtered, and concentrated in vacuo. Silica gel column chromatography gave the desired product (37 mg, 30percent yield).
The synthetic route of 80945-83-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KROPF, Jeffrey, E.; SCHMITT, Aaron; WATKINS, William, J.; XU, Jianjun; GEGE, Christian; (92 pag.)WO2016/96116; (2016); A1;,
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