With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34272-64-5,2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid,as a common compound, the synthetic route is as follows.
EXAMPLE 172 7-beta-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid 2.7 g (0.01 mole) of 7-aminocephalosporanic acid and 1.9 g (0.01 mole) of 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole are suspended in 250 ml of water. Sodium bicarbonate is added until a clear solution has formed. The reaction solution is heated to 50 C. for 4 hours, whilst keeping the pH value constant at the neutral point. The solution is allowed to cool and is extracted several times with ethyl acetate and the aqueous phase is adjusted to a pH value of 2 with 2 N HCl. The precipitate is filtered off, washed several times with alcohol and ether and dried. 3.7 g of the title compound of melting point 195-196 C. (decomposition) are obtained. NMR (d6 -DMSO, 60 MHz): delta=2.17 ppm (s, 3H, =C–CH3), delta=3.52 ppm (AB, 2H, 2–CH2 –), delta=3.68 ppm (s, 2H, =C–CH2 –COO–) delta=4.31 ppm (AB, 2H, 3–CH2 –S–) and delta=4.80 ppm (m, 2H, 6–CH–+7–CH–)., 34272-64-5
As the paragraph descriping shows that 34272-64-5 is playing an increasingly important role.
Reference£º
Patent; Hoechst Aktiengesellschaft; US4278793; (1981); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica