With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.
A solution containing 300 mg of 16h, 180 mul of 5-Br-thiazole, 350 mul of diisopropyl amine, 21mg of PdCl2(benzonitrile)2, 250 mul of IM tri-te/t-butyl phosphine (in toluene), 12 mg of CuI in 2 ml of degassed dioxane was stirred overnight at RT under a N2 atmosphere. The mixture was poured onto 5% aq. NH4CI and extracted with ethyl acetate. The extract was dried, concentrated and the crude material was purified by chromatography over silica gel, using a gradient of heptane/ethyl acetate as eluent. This afforded 320 mg 16i as a colorless oil. Rf 0.45 (heptane/ethyl acetate 1/1). MS-ESI: [M+l] 337.17NMR (CDCl3) delta 8.64 and 7.88 (2x s, 2, thiazole H), 1.40 (m, 2, CH2), 1.48 (s, 9, tertC49), 1.64 (m, 4, 2x CH2), 2.46 (t, 2, CH2), 3.20 (m, 2, CH2), 3.83 (s, 3, OCH3).
3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.
Reference£º
Patent; N.V. ORGANON; LOOZEN, Hubert, Jan, Jozef; TIMMERS, Cornelis, Marius; STOCK, Herman, Thijs; WO2011/12600; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica