Reference of 161798-03-4. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of febuxostat intermediate I, a preparation method of the febuxostat intermediate II, application of the febuxostat intermediate II and a preparation method of the febuxostat intermediate II. The preparation method of the febuxostat product comprises the following steps: preparing febuxostat intermediate I and febuxostat intermediate II; directly adding water and organic alkali hydrolysis reaction in the non-febuxostat intermediate II solution 6.0 – 7.0. The non-febuxostat finished product is high in product purity, high in product purity, high in preparation method yield and low in cost; solid-liquid separation is easily realized; the residual solvent is easily removed in a finished product preparation step. (by machine translation)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of febuxostat intermediate I, a preparation method of the febuxostat intermediate II, application of the febuxostat intermediate II and a preparation method of the febuxostat intermediate II. The preparation method of the febuxostat product comprises the following steps: preparing febuxostat intermediate I and febuxostat intermediate II; directly adding water and organic alkali hydrolysis reaction in the non-febuxostat intermediate II solution 6.0 – 7.0. The non-febuxostat finished product is high in product purity, high in product purity, high in preparation method yield and low in cost; solid-liquid separation is easily realized; the residual solvent is easily removed in a finished product preparation step. (by machine translation)
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Reference£º
Thiazole | C3H7769NS – PubChem,
Thiazole | chemical compound | Britannica