With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.432047-36-4,1-(2-Thiazolyl)ethylamine,as a common compound, the synthetic route is as follows.
Example 78: N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N’-[(1S)-1-(1,3-thiazol-2-yl)ethyl]urea 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (30 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (35 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of (1S)-1-(1,3-thiazol-2-yl)-1-ethylamine (35 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (31 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): delta 1.68 (d, J = 6.8 Hz, 3H), 4.09 (s, 3H), 4.10 (s, 3H), 5.32 – 5.38 (m, 1H), 6.51 (d, J = 6.3 Hz, 1H), 6.55 (br, 1H), 7.06 (d, J = 8.8 Hz, 1H), 7.22 (d, J = 3.2 Hz, 1H), 7.64 (d, J = 1.2 Hz, 1H), 7.66 (d, J = 3.4 Hz, 1H), 7.67 (s, 1H), 7.79 (s, 1H), 8.31 (d, J = 6.3 Hz, 1H), 8.59 (s, 1H), 432047-36-4
432047-36-4 1-(2-Thiazolyl)ethylamine 19896985, athiazole compound, is more and more widely used in various.
Reference£º
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1535910; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica