14527-42-5, Name is Ethyl thiazole-2-carboxylate, molecular formula is C6H7NO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 14527-42-5, category: thiazole
We present a novel series of HIV integrase inhibitors, showing IC50s ranging from 0.01 to over 370 muM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure-activity relationships. Finally, we found a 3D-pharmacophore model, which is composed of a hydrophilic and a hydrophobic domain, providing valuable information for designing other novel types of integrase inhibitors.
We present a novel series of HIV integrase inhibitors, showing IC50s ranging from 0.01 to over 370 muM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure-activity relationships. Finally, we found a 3D-pharmacophore model, which is composed of a hydrophilic and a hydrophobic domain, providing valuable information for designing other novel types of integrase inhibitors.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazole. In my other articles, you can also check out more blogs about 14527-42-5
Reference£º
Thiazole | C3H8329NS – PubChem,
Thiazole | chemical compound | Britannica