In an article, published in an article, once mentioned the application of 4845-58-3, Name is 6-Nitrobenzo[d]thiazole-2(3H)-thione,molecular formula is C7H4N2O2S2, is a conventional compound. this article was the specific content is as follows.category: thiazole
The nuclear peroxisome proliferator-activated receptor gammahas well-validated therapeutic potential in metabolic, inflammatory, and neurodegenerative pathologies, but its activation is also associated with marked adverse effects and novel modes of PPARgammamodulation are required. Here, we report the discovery and profiling of a new PPARgammamodulator chemotype endowed with remarkable potency and a distinct binding mode in the orthosteric PPARgammaligand-binding site. Its R-enantiomer evolved as a eutomer regarding PPARgammaactivation with a high eudysmic ratio. The new PPARgammamodulator revealed outstanding selectivity over the PPARalpha and PPARdeltasubtypes and did not promote adipogenesis in primary human fibroblasts, discriminating it from established agonists.
The nuclear peroxisome proliferator-activated receptor gammahas well-validated therapeutic potential in metabolic, inflammatory, and neurodegenerative pathologies, but its activation is also associated with marked adverse effects and novel modes of PPARgammamodulation are required. Here, we report the discovery and profiling of a new PPARgammamodulator chemotype endowed with remarkable potency and a distinct binding mode in the orthosteric PPARgammaligand-binding site. Its R-enantiomer evolved as a eutomer regarding PPARgammaactivation with a high eudysmic ratio. The new PPARgammamodulator revealed outstanding selectivity over the PPARalpha and PPARdeltasubtypes and did not promote adipogenesis in primary human fibroblasts, discriminating it from established agonists.
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Reference£º
Thiazole | C3H7350NS – PubChem,
Thiazole | chemical compound | Britannica