With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-41-4,5-Thiazolecarboxylic acid,as a common compound, the synthetic route is as follows.
Example 2(S)-N-( 1 -(5-(2-methoxyquinolin-3-yl)-JH-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5 -carboxamide (B 1) A glass tube was charged with thiazole-5-carboxylic acid (1.5 eq.), PS-carbodiimide resin (2 eq.), HOBt (1.7 eq.) and diluted with DCM (0.04 M). The tube was capped and stirred on a rotorfor 10 mm. Then, a solution of A4 in DMF (0.06 M) was added and the reaction mixture was stirred in a rotor for 24 h. After addition of MP-Trisamine resin (10 eq.) the reaction was stirred for additional 24 h. The resulting reaction mixture was filtered through a fitted syringe and washed with DCM. The combined organic solutions were concentrated under reduced pressure to give the tilte compound. MS (ESj C25H28N6035: 493 (M+H).
As the paragraph descriping shows that 14527-41-4 is playing an increasingly important role.
Reference£º
Patent; IRBM SCIENCE PARK S.P.A.; C.N.C.C.S. SCARL COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING; ALTAMURA, Sergio; BIANCOFIORE, Ilaria; BRESCIANI, Alberto; FERRIGNO, Federica; HARPER, Steven; LAUFER, Ralph; ONTORIA ONTORIA, Jesus Maria; MALANCONA, Savina; MONTEAGUDO, Edith; NIZI, Emanuela; ORSALE, Maria Vittoria; PONZI, Simona; PAONESSA, Giacomo; SUMMA, Vincenzo; VENEZIANO, Maria; WO2014/67985; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica