57268-16-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57268-16-3,5-Bromo-2-methylthiazole,as a common compound, the synthetic route is as follows.
STEP 3 : To a solution of 4- {5-[(4-fluorophenyl)methyl]-6-methylpyrimidin- 4-yl}-7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2,3,4,5-tetrahydro-l,4- benzoxazepine (46 mg, 0.096 mmol) and 5-bromo-2-methyl-l,3-thiazole (17 mg, 0.096 mmol) in dioxane (5 rnL) was added potassium carbonate (66 mg, 0.48 mmol) and [1,1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium (II) dichloromethane adduct (8 mg, 0.0096 mmol). The reaction mixture was stirred at 100 0C for 20 h, and then cooled to room temperature. The reaction mixture was concentrated, and then partitioned between ethyl acetate (100 mL) and water (50 mL). The layers were separated and the organic layer was washed with brine, dried over magnesium sulfate then filtered and concentrated. The residue was taken up in a minimum of acetonitrile and purified by preparative reverse phase HPLC to afford 4-{5-[(4-fluorophenyl)methyl]-6- methylpyrimidin-4-yl}-7-(2-methyl-l,3-thiazol-5-yl)-2,3,4,5-tetrahydro-l,4- benzoxazepine (18 mg) as a white powder. 1H NMR (400 MHz, DMSO-D6): 8.47 (s, IH), 7.77 (s, IH), 7.41 (dd, IH), 7.19-7.05 (m, 4H), 6.96 (d, IH), 6.83 (d, IH), 4.47 (s, 2H), 4.27 (t, 2H), 3.93 (s, 2H), 3.74 (t, 2H), 2.67 (s, 3H), 2.14 (s, 3H); MS (EI) for C25H23FN4OS: 446 (M+).
As the paragraph descriping shows that 57268-16-3 is playing an increasingly important role.
Reference£º
Patent; EXELIXIS, INC.; ANAND, Neel, Kumar; BAIK, Tae-Gon; BLAZEY, Charles, M.; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen; JOSHI, Anagha; KIM, Angie, Inyoung; MANALO, Jean-Claire, Limun; PETO, Csaba, J.; RICE, Kenneth, D.; TSANG, Tsze, H.; WO2010/135568; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica