In an article, published in an article, once mentioned the application of 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,molecular formula is C10H10N2O2S, is a conventional compound. this article was the specific content is as follows.category: thiazole
Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with beta-ketoesters and amides have been developed, controlled by the reagents employed. With the Br¡ãnsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d]imidazo[2,1-b]thiazoles are synthesized via attack at the alpha-carbon and keto carbon of the beta-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)3, results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones instead.
Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with beta-ketoesters and amides have been developed, controlled by the reagents employed. With the Br¡ãnsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d]imidazo[2,1-b]thiazoles are synthesized via attack at the alpha-carbon and keto carbon of the beta-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)3, results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones instead.
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Reference£º
Thiazole | C3H10629NS – PubChem,
Thiazole | chemical compound | Britannica