51640-36-9, 2-Chlorothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
51640-36-9, Step 1: Ethyl 2-(6-(5-cyanothiazol-2-yloxy)-l-hydroxy-4-methyl-l,3- dihydrobenzo[c] [1,2] oxaborol-3-yl) acetate[0665] To a mixture of ethyl 2-(l ,6-dihydroxy-4-methyl-l ,3- dihydrobenzo[c][l,2]oxaborol-3-yl)acetate (3.75 g, 15 mmol, 1 eq.) and 2- chlorothiazole-5-carbonitrile (3.25 g, 22.5 mmol, 1.5 eq.) in 100 ml DMF was added cesium carbonate (14 g, 45 mmol, 3 eq.). The reaction was heated at 7O0C for two hours. It was then quenched by water, extracted with EtOAc, washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude was purified by column chromatography (4.3 g, yield 80%). MS (ESI) m/z = 111 [2M+H]+.
51640-36-9 2-Chlorothiazole-5-carbonitrile 1485222, athiazole compound, is more and more widely used in various.
Reference£º
Patent; ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding; WO2011/17125; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica