533-30-2,533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[00405] Step 2: A mixture of 6-chloro-4-((lS,2S)-2,3-dihydroxy-l- phenylpropylamino)nicotinonitrile (0.108 g, 0.356 mmol), benzo[d]thiazol-6-amine (0.187 g, 1.244 mmol) and NMP (1.422 mL) was stirred at 150 ¡ãC for 1 hour in a microwave reactor. The vessel was cooled to room temperature, diluted with water and filtered. Following drying on a buchner funnel, 6-(benzo[d]thiazol-6-ylamino)-4- ((lS,2S)-2,3-dihydroxy-l-phenylpropylamino)nicotinonitrile (0.122 g, 0.292 mmol, 82 percent yield) was collected as a yellowish solid. LC-MS (m/z, M+l= 418), Waters sunfire 4.6x50mm C18 5um 4 min/1 min hold time 0-100percent (A-B) A=10percent MeOH-90percent water – 0.1percentTFA, B=90percent MeOH-10percent water – 0.1percentTFA RT= 2.06.
The synthetic route of 533-30-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; DODD, Dharmpal, S.; MUSSARI, Christopher, P.; BHIDE, Rajeev, S.; NAIR, Satheesh Kesavan; PAIDI, Venkatram Reddy; KUMAR, Sreekantha Ratna; BANERJEE, Abhisek; SISTLA, Ramesh; PITTS, William, J.; HYNES, John; WO2013/106614; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica