Electric Literature of 86978-24-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 86978-24-7, C13H18N2O4S. A document type is Patent, introducing its new discovery.
The invention relates to a head spore card side chain acid preparation method, which belongs to the technical field of pharmaceutical intermediates. The preparation method is under the protection of nitrogen to the alcohol in the organic solvent in a double-ketene, then instillment bromide reaction, adding methylene chloride and water mixed fluid quenching reaction, separating the organic phase, the organic phase is added to the acetic acid, after cooling at the same time dropping propionaldehyde and organic reaction catalyst A, then adding thiourea to react, by reduced pressure distillation to concentrate, the concentrated solution is added in dichloromethane, di-T-n-butyl and organic reaction catalyst B, then adding alkali to carry out the reaction, the temperature of the hydrochloric acid then drop crystallization, filtered, isopropyl alcohol aqueous solution and washing, and drying to obtain (Z)- 2 – (2 – tert-butoxycarbonyl amino thiazole – 4 – yl) – 2 – pentenoic acid, i.e. side chain acidspore card. The invention uses two-ketene as the starting material, less side reaction, high yield, high product purity, mild reaction conditions, more easy to realize industrial production. (by machine translation)
The invention relates to a head spore card side chain acid preparation method, which belongs to the technical field of pharmaceutical intermediates. The preparation method is under the protection of nitrogen to the alcohol in the organic solvent in a double-ketene, then instillment bromide reaction, adding methylene chloride and water mixed fluid quenching reaction, separating the organic phase, the organic phase is added to the acetic acid, after cooling at the same time dropping propionaldehyde and organic reaction catalyst A, then adding thiourea to react, by reduced pressure distillation to concentrate, the concentrated solution is added in dichloromethane, di-T-n-butyl and organic reaction catalyst B, then adding alkali to carry out the reaction, the temperature of the hydrochloric acid then drop crystallization, filtered, isopropyl alcohol aqueous solution and washing, and drying to obtain (Z)- 2 – (2 – tert-butoxycarbonyl amino thiazole – 4 – yl) – 2 – pentenoic acid, i.e. side chain acidspore card. The invention uses two-ketene as the starting material, less side reaction, high yield, high product purity, mild reaction conditions, more easy to realize industrial production. (by machine translation)
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Reference£º
Thiazole | C3H101NS – PubChem,
Thiazole | chemical compound | Britannica