41731-39-9, 2-Bromo-4-(trifluoromethyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of oxetan-3-yl 4-(1-(phenylsulfonyl)-2-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate (250 mg, 342 mupiiotaomicron), 2-bromo-4- (trifluoromethyl)thiazole (120 mg, 513 muiotaetaomicron), Cul (65 mg, 342 mmol), and Pd(PPh3)4 (197 mg, 171 muetaiotaomicron) in toluene (10 mL) was degassed with N2, and then stirred at 100C for 16 h under N2. The mixture was cooled to room temperature and concentrated. The residue was directly purified by silica gel chromatography (ethyl acetaterpetroleum ether = 3: 10) to give the title product (70 mg, yield 35%) as a light yellow solid. MS (ES+) C25H22F3N5O5S2 requires: 593, found: 594 [M+H]+.
41731-39-9, 41731-39-9 2-Bromo-4-(trifluoromethyl)thiazole 23149887, athiazole compound, is more and more widely used in various.
Reference£º
Patent; BLUEPRINT MEDICINES CORPORATION; BRUBAKER, Jason D.; FLEMING, Paul E.; KIM, Joseph L.; WILLIAMS, Brett; HODOUS, Brian L.; (238 pag.)WO2019/79649; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica