Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 96-53-7, Name is 4,5-Dihydrothiazole-2-thiol, molecular formula is C3H5NS2. In an article, author is Sahin, Omer,once mentioned of 96-53-7, Recommanded Product: 4,5-Dihydrothiazole-2-thiol.
Synthesis, characterization, molecular docking and in vitro screening of new metal complexes with coumarin Schiff base as anticholine esterase and antipancreatic cholesterol esterase agents
In this work, Combining coumarin and thiazole with 3-tertiary butyl salicylaldehyde into in a single molecule, new Schiff base (CTS), and its metal complexes with palladium and platinum were synthesized and characterized by using well-known spectroscopic techniques such as H-1-NMR, C-13-NMR, FT-IR and LC-MS. And also, the formation of these complexes were confirmed by magnetic moment and conductivity measurements. The photophysical properties of CTS were studied and it was observed that the Schiff base has a sensitivity to CN-, F-, and AcO- anions. The quantum chemical calculations based on density functional theory (DFT) were done for explaining some experimental, structural, and spectroscopic data of the dyes. Also, to evaluate the binding interactions between the ligand (CTS) and its metal complexes and enzymes, molecular docking studies were performed and all the compounds tested to determine its inhibition potential against the cholinesterase (AChE and BChE) and pancreatic cholesterol esterase (CEase) enzymes. Both in vitro and in silico the results showed that all of the compounds could act as potent inhibitors of AChE, BChE, and CEase. The Pt (II) complex showed the most potent inhibitory property against all of the enzymes with IC50 values of 12 mu M for AChE, 23 mu M for BChE, and 21 mu M for CEase.
Interested yet? Keep reading other articles of 96-53-7, you can contact me at any time and look forward to more communication. Recommanded Product: 4,5-Dihydrothiazole-2-thiol.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica