With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95453-58-0,2-Chlorothiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.
95453-58-0, Example 262A 1-{[(2-chloro-1,3-thiazol-5-yl)methylene]amino}-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one The product of Example 226D (0.070 g, 0.196 mmol) was reacted with 2-chloro-1,3-thiazole-5-carbaldehyde (0.157 mL, 1.06 mmol) in N,N-dimethylacetamide (1.2 mL) in a sealed tube at 110 C. for 35 minutes in a microwave reactor. The reaction mixture was cooled to 25 C. and concentrated. The resulting residue was triturated with ethyl acetate and filtered to give the title compound.
As the paragraph descriping shows that 95453-58-0 is playing an increasingly important role.
Reference£º
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pamela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/162285; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica