With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.
To a stirred solution of 1.00 g of 1,3-thiazole-2-carboxaldehyde in 10 mL of tetrahydrofuran was added 0.334 g of sodium borohydride at room temperature. To the mixture was dropped 1 mL of methanol, and the mixture was stirred at the same temperature for 30 minutes. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 0.344 g of 1,3-thiazol-2-ylmethanol.1H-NMR (CDCl3) delta ppm: 3.11 (1H, br s), 4.97 (2H, s), 7.32 (1H, d, J=3.2Hz), 7.75 (1H, d, J=3.2Hz)
10200-59-6, The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Kissei Pharmaceutical Co., Ltd.; EP1443041; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica