With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
18903-18-9, Intermediate 4 5-Amino-thiazole-4-carboxylic acid ethyl ester (250mg, 1.453mmol) and triethylamine (1 .02ml_, 7.265mmol) were dissolved in 1 ,4-dioxan (6ml_). To this, 2- chloro-5-(trifluoromethyl)benzene-1 -sulfonyl chloride (0.3mL, 1 .744mmol) was added at room temperature and stirred for 16 hours. The mixture was concentrated in vacuo and extracted with ethyl acetate. The organic layer was washed with 1 N hydrochloric acid solution and water. The organic layer was dried with Na2S04, filtered and concentrated in vacuo. The residue was triturated with n-pentane, the product collected by filtration and dried under vacuum to give Intermediate 4 (340mg). LCMS (Method 26) Rt 2.63 min; m/z(M+H)+ 415
18903-18-9 Ethyl 5-aminothiazole-4-carboxylate 12620181, athiazole compound, is more and more widely used in various.
Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica