Related Products of 7305-71-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 7305-71-7, Name is 2-Amino-5-methylthiazole, SMILES is C1=C(SC(=N1)N)C, belongs to thiazoles compound. In a article, author is Kesari, Chekrapani, introduce new discover of the category.
Synthesis of thiazole linked chalcones and their pyrimidine analogues as anticancer agents
A series of nine novel thiazole linked chalcones, (E)-3-(4-methyl-2-(4(trifluoromethyl)phenyl)thiazol-5-yl)-1-phenylprop-2-en-1-one derivatives 7-15 were synthesized. To establish the structure-activity relationship (SAR), furthermore, the corresponding, ring-closed pyrimidine analogs 17-23 were synthesized. The derivatives thus obtained were evaluated for their anti-cancer activity against three genetically different colorectal cancer (CRC) cell lines. Thiazole derivatives 7, 9, and10 showed anti-cancer activity with GI50 values ranging from 0.19 to 100 mu M. Importantly, compounds 7 and 10 outperformed the standard drug cisplatin in the tested cell lines and thus show promise for further optimization. Some of pyrimidine derivatives retain activity comparable to cisplatin in the HT-29 cell line, e.g. compounds 17 and 18 with IC50 of 25 mu M, however, none of these compounds demonstrated improved antiproliferative activity as compared with the starting thiazole, thus the enone linker was critical for obtaining more active compounds in this series.
Related Products of 7305-71-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 7305-71-7 is helpful to your research.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica