Application of 76824-35-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 76824-35-6, Name is Famotidine, SMILES is N=C(NS(=O)(N)=O)CCSCC1=CSC(NC(N)=N)=N1, belongs to thiazoles compound. In a article, author is Mahmoud, Huda K., introduce new discover of the category.
Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity
Novel 2-indolinone thiazole hybrids were designed and synthesized as VEGFR-2 inhibitors based on sunitinib, an FDA-approved anticancer drug. The proposed structures of the prepared 2-indolinone thiazole hybrids were confirmed based on their spectral data and CHN analyses. The target compounds were screened in vitro for their anti-VEGFR-2 activity. All tested compounds exhibited a potent submicromolar inhibition of VEGFR-2 kinase with IC50 values ranging from 0.067 to 0.422 mu M, relative to sunitinib reference drug (IC50 = 0.075 +/- 0.002 mu M). Compounds 5, 15a, 15b, 17, 19c displayed excellent VEGFR-2 inhibitory activity, comparable or nearly equipotent to sunitinib. Compound 13b stood out as the most potent against VEGFR-2 showing IC50 value of 0.067 +/- 0.002 mu M, lower than that of sunitinib. In addition, the most potent derivatives were assessed for their anticancer activity against two renal cancer cell lines. Compound 13b (IC50 = 3.9 +/- 0.13 mu M) was more potent than sunitinib (IC50 = 4.93 +/- 0.16 mu M) against CAKI-1 cell line. Moreover, thiazole 15b displayed excellent anticancer activity against CAKI-1 cell line (IC50 = 3.31 +/- 0.11 mu M), superior to that of sunitinib (IC50 = 4.93 +/- 0.16 mu M). Thiazole 15b was also equipotent to sunitinib (IC50 = 1.23 +/- 0.04 mu M) against A498 cell line. Besides, compound 15b revealed a safety profile much better than that of sunitinib against normal human renal cells. Furthermore, a docking study revealed a proper fitting of the most active compounds into the ATP binding site of VEGFR2, rationalizing their potent anti-VEGFR-2 activity. (c) 2020 Elsevier Masson SAS. All rights reserved.
Application of 76824-35-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 76824-35-6.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica