Electric Literature of 181124-40-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 181124-40-3, Name is Benzo[d]thiazole-6-sulfonyl chloride, SMILES is O=S(C1=CC=C2N=CSC2=C1)(Cl)=O, belongs to thiazoles compound. In a article, author is Bolakatti, Girish, introduce new discover of the category.
Novel series of benzo[d]thiazolyl substituted-2-quinolone hybrids: Design, synthesis, biological evaluation and in-silico insights
A novel series of 3-(2-(4-(substituted-benzo[d]thiazol-2-yl)phenylamino)acetyl)-4-hydroxy-1-methyl/phenyl quinolin-2(1H)-one (7a-f and 8a-f) were synthesized. Reaction of appropriately substituted-2-(4-amino phenyl)benzo[d]thiazole (4a-f) with 3-(2-bromoacety1)-4-hydroxy-l-methyl/phenyl quinolin2(1H)-one (5/6) in the presence of glacial acetic acid resulted in desired compounds. Structures of the synthesized compounds were characterized based on their spectral (IR, H-1 NMR, C-13 NMR and MS) and elemental analysis. The cytotoxicity screening studies revealed that MCF-7 and WRL68 cancer cells were sensitive to all the tested compounds. Out of twelve novel hybrids, compound 8f displayed the most significant anticancer activity. Docking studies were performed in order to understand the binding mode of the title compounds at the active site of the target enzyme (EGFR tyrosine kinase, 1M17). Compounds 8f and 7f displayed prominent and conserved binding interactions against 1M17. In addition, compounds 7e, 7f, 8e, and 8f exhibited interesting in vitro antibacterial activity, especially against Gram-negative bacteria E. coli. In summary, the novel benzo[d]thiazolyl substituted-2-quinolone hybrid (8f) could be considered as promising hit and could be further exploited for developing potential anticancer/antimicrobial agents. (C) 2020 Elsevier B.V. All rights reserved.
Electric Literature of 181124-40-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 181124-40-3.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica