Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 55981-09-4, 55981-09-4, Name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, SMILES is CC(OC1=CC=CC=C1C(NC2=NC=C([N+]([O-])=O)S2)=O)=O, belongs to thiazoles compound. In a document, author is Rajan, Remya, introduce the new discover.
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring
Glutamatergic N-Methyl-D-aspartate (NMDA) receptors are heterotetrameric ion channels that can be comprised of different subunits. GluN2A subunit-containing NMDA receptors are associated with diseases like anxiety, depression, and schizophrenia. However, the exact contribution of these NMDA receptor subtypes is still unclear. To understand better the role of the GluN2A-containing receptors, novel ligands were designed. In co-crystallization with the isolated binding site, TCN-201 (1) and analogs adopt a U-shape conformation with parallel orientation of rings A and B. In order to increase the pi/pi-interactions between these rings, ring B of TCN-201 was replaced bioisosterically by different electron-rich thiazole, oxazole, and isoxazole heterocycles. The inhibitory activity was measured by two-electrode voltage clamp experiments with Xenopus laevis oocytes expressing GluN2A-containing NMDA receptors. It was found that 21c, 31a, 37a, and 37b were able to inhibit the ion channel. The isoxazole derivative 37b was the most potent negative allosteric modulator displaying 40% of the TCN-201 activity at a concentration of 10 mu M. (c) 2020 Elsevier Masson SAS. All rights reserved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 55981-09-4. Product Details of 55981-09-4.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica