Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C4H6N2S, 7305-71-7, Name is 2-Amino-5-methylthiazole, molecular formula is C4H6N2S, belongs to thiazoles compound. In a document, author is Ye, Liwei, introduce the new discover.
An Efficient Precatalyst Approach for the Synthesis of Thiazole-Containing Conjugated Polymers via Cu-Catalyzed Direct Arylation Polymerization (Cu-DArP)
Over the past decade, direct arylation polymerization (DArP) has emerged as a facile and sustainable methodology for the synthesis of conjugated polymers. Recently, we developed Cu-catalyzed DArP (Cu-DArP) as a low-cost, Pd-free synthetic pathway, which enables conjugated polymers to be synthesized with high molecular weights and minimization of defects. However, the lack of study on the use of Cu-precatalysts in small-molecule direct arylation poses significant limitations for Cu-DArP to potentially overtake conventional Pd-catalyzed methodology, such as the low solubility and stability of the previously employed Cul. Therefore, in this report, we decide to explore the utility of a well-defined, easy-to-prepare, highly soluble, and stable precatalyst, Cu(phen)(PPh3)Br, as an alternative to the Cul, 1,10-phenanthroline catalytic system previously used for Cu-DArP. Herein, we report a drastic improvement of Cu-DArP methodology for the synthesis of 5,5′-bithiazole (5-BTz)-based conjugated polymers enabled by an efficient precatalyst approach, affording polymers with good M-n (up to 163 kDa) and excellent yields (up to 79%). H-1 NMR studies reveal the exclusion of homocoupling defects, which further verifies the excellent stability of Cu(phen)(PPh3)Br compared to CuI. Furthermore, we were able to decrease the catalyst loading from 15 mol % to only 5 mol % (M-n of 11.8 kDa, 64% yield), which is unprecedented when aryl bromides are employed for Cu-DArP. Significantly, 5-BTz was shown to be inactive under various of Pd-DArP conditions, which demonstrates the high compatibility of Cu-DArP as the only pathway for the C-H activation of the 5-BTz unit and a clear case demonstrating an advantage of Cu-DArP relative to Pd-DArP.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 7305-71-7. Formula: C4H6N2S.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica