Chemistry is an experimental science, HPLC of Formula: C4H6N2S, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 7305-71-7, Name is 2-Amino-5-methylthiazole, molecular formula is C4H6N2S, belongs to thiazoles compound. In a document, author is Yawson, Gideon K..
Ruthenium(III) complexes with imidazole ligands that modulate the aggregation of the amyloid-beta peptide via hydrophobic interactions
Alzheimer’s disease (AD) is the most common form of dementia, characterized by extracellular protein deposits, comprised primarily of the peptide amyloid-beta (A beta), are a pathological indicator of the disease. Commonly known as A beta plaques, these deposits contain a relatively high concentration of metals, making metallotherapeutics uniquely suited to target soluble A beta, thereby limiting its aggregation and cytotoxicity. Ruthenium based complexes are promising candidates for advancement, as the complex PMRU20 (2-aminothiazolium [trans-RuCl4(2-aminothiazole)(2)]) and several thiazole-based derivatives were found to prevent the aggregation of A beta, with hydrogen-bonding functional groups improving their performance. Further investigation into the impact of the heteroatom in the azole ring on the activity of Ru complexes was achieved through the synthesis and evaluation of a small set of imidazole-based compounds. The ability of the complexes to prevent the aggregation of A beta was determined where the same sample was subjected to analysis by three complementary methods: ThT fluorescence, dynamic light scattering (DLS), and transmission electron microscopy (TEM). It was found that hydrophobic interactions, along with hydrogen-bonding via the imidazole nitrogen heteroatom, promoted interactions with the A beta peptide, thereby limiting its aggregation. Furthermore, it was found that having rapid and sequential exchange proved detrimental as it resulted in a decreased association with A beta. These results highlight important considerations between a balance of intermolecular interactions and ligand exchange kinetics in the design of further therapeutic candidates.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 7305-71-7. HPLC of Formula: C4H6N2S.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica