In an article, author is Cha, Min-Jeong, once mentioned the application of 7305-71-7, HPLC of Formula: C4H6N2S, Name is 2-Amino-5-methylthiazole, molecular formula is C4H6N2S, molecular weight is 114.17, MDL number is MFCD00078317, category is thiazoles. Now introduce a scientific discovery about this category.
Solid-phase parallel synthesis of 1,3-thiazole library adorned with dipeptidyl chains
In this study, we report a solid-phase synthesis of 1,3-thiazole based peptidomimetic molecules. The key reaction step is dehydrative cyclization of thiourea resin intermediate with 2-bromo-1-(3-nitrophenyl) ethanone to afford 1,3-thiazole core with benzyl-nitro group attached. Further modification of the nitro group with peptide elongations yielded resin-bound N-benzyl-1,3-thiazole derivatives with short peptide chains at C4 and C5 positions. Cleavage from the resin delivered compounds in moderate yields. Synthesized compounds had high purities (>97%). (C) 2020 Elsevier Ltd. All rights reserved.
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Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica