Synthetic Route of 121-66-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 121-66-4, Name is 5-Nitrothiazol-2-amine, SMILES is NC1=NC=C([N+]([O-])=O)S1, belongs to thiazoles compound. In a article, author is El-Deen, I. M., introduce new discover of the category.
Design, Synthesis, and Anticancer Activity of New Derivatives of Thiazole and Imidazole
A number of nitrogen heterocyclic derivatives, namely 1,3-thiazole and imidazolidine-2-thione, have been synthesized and their structures confirmed by IR, 1H and 13C NMR, and mass spectra. Cytotoxic activity of some synthesized products has been tested against human hepatocellular carcinoma (HepG2) cell line using the MTT assay. The most potent anti-proliferative agent demonstrates activity 2-fold higher than the reference compound doxorubicin. Three compounds have been characterized by IC50 value against VEGFR-2. The cell cycle analysis of compound 6 has demonstrated cell cycle arrest at G1 phase and accumulation of cells in pre-G1 phase indicating that cytotoxic activity proceeds via apoptotic pathway.
Synthetic Route of 121-66-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 121-66-4.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica