A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7305-71-7, Name is 2-Amino-5-methylthiazole, molecular formula is C4H6N2S. In an article, author is Jagadale, Shivaji,once mentioned of 7305-71-7, Recommanded Product: 7305-71-7.
Synthesis, characterization and antimicrobial screening of new pyrazolyl-1,2,3-triazolyl-thiazolyl-ethanol derivatives
Novel 2-{4-[3-aryl-1-phenylpyrazol-4-yl]-1,2,3-triazol-1-yl}-1-(4-methyl-2-aryl-1,3-thiazol-5-yl)ethanol derivatives, (5a-l) are synthesized by applying click reaction between 4-ethynyl-1,3-diphenyl-1H-pyrazole, (2a-c) and 2-azido-1-(4-methyl-2-arylthiazol-5-yl)ethanone (3a-d) followed by reduction of carbonyl with sodiumborohydride. The starting compounds 4-ethynyl-3-aryl-1-phenyl-1H-pyrazole (2a-c) were synthesized in good yield from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde (1a-c) using Bestmann-Ohira reagents.The newly synthesized azole derivatives (5a-l) were screened for in vitro antimicrobial activity against Proteus mirabilis (NCIM2388), Escherichia coli (NCIM2065), Bacillus subtilis (NCIM2063), Staphylococcus albus (NCIM 2178) and in vitro antifungal activity against Candida albicans (NCIM 3100), Aspergillus niger (ATCC 504). 2-{4-[3-(4-Methoxyphenyl)-1-phenylpyrazol-4-yl]-1,2,3-triazol-1-yl}-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethanol, (5a) 2-{4-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]-1,2,3-triazol-1-yl}-1-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethanol, (5 h) 2-{4-[3-(4-bromophenyl)-1-phenylpyrazol-4-yl]-1,2,3-triazol-1-yl}-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethanol, (5i) 2-{4-[3-(4-bromophenyl)-1-phenylpyrazol-4-yl]-1,2,3-triazol-1-yl}-1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethanol (5j) and 2-{4-[3-(4-bromophenyl)-1-phenylpyrazol-4-yl]-1,2,3-triazol-1-yl}-1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethanol, (5k) reportedgoodantifungal activity against A. niger with MIC 31.25-62.5 mu g/mL. Most of the compounds showed moderate activity against bacterial strains. The antifungal activity of pyrazolyl-1,2,3-triazolyl-thiazolylethanol derivatives suggested that these derivatives could lead to compounds for treatment against fungal infection.
Interested yet? Keep reading other articles of 7305-71-7, you can contact me at any time and look forward to more communication. Recommanded Product: 7305-71-7.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica