Discovery of 2-Amino-5-methylthiazole

Reference of 7305-71-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 7305-71-7 is helpful to your research.

Reference of 7305-71-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7305-71-7, Name is 2-Amino-5-methylthiazole, SMILES is C1=C(SC(=N1)N)C, belongs to thiazoles compound. In a article, author is Desai, Nisheeth, introduce new discover of the category.

Quinazoline clubbed thiazole and 1,3,4-oxadiazole heterocycles: synthesis, characterization, antibacterial evaluation, and molecular docking studies

In search of potent antibacterial agents, a series of novel quinazolines, bearing thiazole and 1,3,4-oxadiazole heterocycles 6a-j (3-(4-methyl-5-(4-((arylamino)methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)-2-phenylquinazolin-4(3H)-ones) were synthesized and the structures of the compounds were elucidated by standard spectroscopic techniques. In order to evaluate their antibacterial potential, the antibacterial assay of synthesized compounds 6a-j was performed against MTCC strains, wherein compounds 6d (3-(4-methyl-5-(4-(((4-nitrophenyl)amino)methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)-2-phenylquinazolin-4(3H)-one) (Escherichia coli, MIC = 100 mu g mL(-1)) and 6e (3-(5-(4-(((2-chlorophenyl)amino)methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-4-methylthiazol-2-yl)-2-phenylquinazolin-4(3H)-one) (E. coli, MIC = 62.5 mu g mL(-1)) were most active against Gram-negative bacteria while compound 6f (3-(5-(4-(((4-chlorophenyl)amino)methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-4-methylthiazol-2-yl)-2-phenylquinazolin-4(3H)-one) (Staphylococcus aureus, MIC = 50 mu g mL(-1)) was most active against Gram-positive bacteria. Furthermore, molecular docking simulation was performed to determine the probable binding mode and affinity of the synthesized compounds toward bacterial DNA gyrase. The preliminary results pave the way for further designing the thiazole based 1,3,4-oxadiazoles heterocycles for enhancing their potency as antibacterial agents.

Reference of 7305-71-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 7305-71-7 is helpful to your research.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica