2289-75-0, 4,5-Dimethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example No. 149Preparation of (4 , 5 -Dimethyl-thiazol-2-yl) – (8-methoxy-2H- pyrazolo [3 , 4-c] quinolin-4 -yl) -amine4 , 5-dimethylthiazol-2 -amine (0.4 mmol 2 eq. , ) was dissolved in THF (dry, 3mL) in a microwave vial (2-5mL) LiHMDS 2M in THF(0.6 mmol 4eq.) was added. The mixture was stirred for 20 min at r.t. and then added to a solution of 4-chloro-8-methoxy-2-(4 -methoxybenzyl) -2H-pyrazolo [3 , 4-c] quinoline (0.16 mmol, leq.) in pyridine (2mL) . The reaction mixture was irradiated in a microwave reactor for 20 min at 200 C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 325.1205 g/molHPLC-MS: analytical method Brt: 2.397 min – found mass: 326.1 (m/z+H), 2289-75-0
The synthetic route of 2289-75-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; KOESTLER, Roland; YEHIA, Nasser; WO2012/143143; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica