541-58-2, 2,4-Dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
541-58-2, The 2,4-dimethylthiazol-5-ylsulphonyl chloride used as a starting material is commercially available and is also described in J. Het. Chem., 1981, 18., 997. The material may also be prepared as follows :- o Chlorosulphonic acid (20 ml) was cooled to 15C in an ice/methanol bath.2,4-Dimethylthiazole (11.32 g) was added dropwise over 45 minutes, with the evolution of hydrogen chloride gas during the addition. The mixture so obtained was heated to 140-1500C for 16 hours. The resultant mixture was cooled to 110-120C and finely powdered phosphorus pentachloride (41.6 g) was added in small portions, with the evolution of further hydrogen 5 chloride gas during the addition. The mixture so obtained was heated to 12O0C for 1 hour. The mixture was cooled to ambient temperature and poured slowly into a vigorously stirred mixture of ice (200 g) and water (200 ml). The mixture so obtained was stirred for 30 minutes. The mixture was extracted with methylene chloride. The organic extract was dried over magnesium sulphate and purified by chromatography on silica using increasingly polar Q mixtures of isohexane and diethyl ether as eluent. There was thus obtained2,4-dimethylthiazol-5-ylsulphonyl chloride as a yellow oil (18.4 g); 1H NMR Spectrum: (CDCl3) 2.76 (3H, s), 2.77 (3H, s).
As the paragraph descriping shows that 541-58-2 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/129052; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica