With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133840-96-7,2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole,as a common compound, the synthetic route is as follows.
General procedure: 2-Chloro-6-trifluoromethoxy-benzothiazole (1.27 g, 5 mmol)was dissolved in 10 mL ethylamine aqueous solution. Theresultant mixture was stirred at room temperature overnight.The solvent was removed under reduced pressure. Theresidue was dissolved in CH2Cl2 and washed three timeswith water, dried over anhydrous Na2SO4, filtered and thesolvent completely removed. The crude material was purifiedby column chromatography over silica used dichloromethaneas eluent to give compound 4a as a whiteamorphous powder (1.11 g, 84.7%). Compounds 4b-4iwere also prepared by the same procedure from compound3 with n-butylamine, diaethylamin, cyclohexylamine, pyrrolidine,piperidine, morpholine, and 4-methylpiperidine,respectively. Spectroscopic data of N-alkylated derivativesof riluzole were given as follow., 133840-96-7
133840-96-7 2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole 10037924, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Wu, Xiang-Long; Liu, Liu; Li, You-Jia; Luo, Jie; Gai, Dong-Wei; Lu, Ting-Li; Mei, Qi-Bing; Medicinal Chemistry Research; vol. 27; 5; (2018); p. 1374 – 1383;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica