45865-42-7, 5-(tert-Butyl)-4-methylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To the solution of 5-tert-Butyl-4-methyl-thiazol-2-ylamine (1.12 g, 6.6 mmol) in dryDMF (20 mL) was added triethylamine (0.92 mL, 1 eq). 2,2,2-trichloroethyl chloroformate (0.9 mL, 6.6 mmol) was added in a dropwise manner at room temperature. The reaction mixture was stirred at room temperature for 3 hrs. Dry DMF (40 mL) was added, washed with brine (320 mL), water (220 mL), dried, filtered, concentrated to afford compound 4, (5-tert-butyl-4-methyl-thiazol-2-yl)-carbamic acid 2,2,2-trichloro-ethyl ester (1.40 g, 4.0 mmol, 61%) as a white solid.MS: 347.0 (M+1)1HNMR (DMSO-d6) ppm: 1.26 (9H, s), 2.12 (3H, s), 4.90 (2H, s)
The synthetic route of 45865-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Du, Xiaomin; Hao, Yan; Zhang, Lanying; US2010/298385; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica