399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of compound 21 (300 mg, 0.900 mmol,1.0 equiv) in n-butanol (5 ml) was added 2-chloro-6-fluorobenzo[d]thiazole (202 mg, 1.1 mmol, 1.1 equiv) and the reaction mixture was stirred at 70 C followed by the addition of 4.0 M HCl (131 mg). The resulting reaction mixture was stirred at 90 C for 16 h. Following reaction completion the solvent was removed under reduced pressure and the compound was purified by flash column chromatography using 10:90 EtOAc:Pet ether to yield methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate (130 mg, 29%) as a solid compound. To this butanoate ester (105 mg, 0.216 mmol) in THF (2 ml) was added 1.0 N lithium hydroxide solution (45 mg, 1.1 mmol,1.1 equiv) and the reaction mixture was stirred at rt for 4 h. Following reaction completion THF was removed under reduced pressure and dil. HCl was added to acidify the reaction mixture. The solid that precipitated as a result was filtered, washed with water,and dried to yield (70 mg, 68%) of the title compound as a white solid compound.
399-74-6, As the paragraph descriping shows that 399-74-6 is playing an increasingly important role.
Reference£º
Article; Kadam, Kishorkumar S.; Jadhav, Ravindra D.; Kandre, Shivaji; Guha, Tandra; Reddy, M. Mahesh Kumar; Brahma, Manoja K.; Deshmukh, Nitin J.; Dixit, Amol; Doshi, Lalit; Srinivasan, Shaila; Devle, Jayendra; Damre, Anagha; Nemmani, Kumar V. S.; Gupte, Amol; Sharma, Rajiv; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 337 – 347;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica