The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.234445-61-5, Name is 2-Isopropylthiazole-4-carboxylic acid, molecular formula is C7H9NO2S. In a Article，once mentioned of 234445-61-5, Safety of 2-Isopropylthiazole-4-carboxylic acid
Discovery of Novel Small-Molecule Inhibitors of NF-kappaB Signaling with Antiinflammatory and Anticancer Properties
Excessive NF-kappaB activation contributes to the pathogenesis of numerous diseases. Small-molecule inhibitors of NF-kappaB signaling have significant therapeutic potential especially in treating inflammatory diseases and cancers. In this study, we performed a cell-based high-throughput screening to discover novel agents capable of inhibiting NF-kappaB signaling. On the basis of two hit scaffolds from the screening, we synthesized 69 derivatives to optimize the potency for inhibition of NF-kappaB activation, leading to successful discovery of the most potent compound Z9j with over 170-fold enhancement of inhibitory activity. Preliminary mechanistic studies revealed that Z9j inhibited NF-kappaB signaling via suppression of Src/Syk, PI3K/Akt, and IKK/IkappaB pathways. This novel compound also demonstrated antiinflammatory and anticancer activities, warranting its further development as a potential multifunctional agent to treat inflammatory diseases and cancers.
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 234445-61-5 is helpful to your research., Safety of 2-Isopropylthiazole-4-carboxylic acid
Reference：
Thiazole | C3H3556NS – PubChem,
Thiazole | chemical compound | Britannica