2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.8 2-(2-(2-Fluorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (12) Compound 12 was prepared through 2-fluorophenylacetic acid, obtained a white solid in 75% yield. Mp 154.3-155.5 C. 1H NMR (400 MHz, DMSO-d6) delta 7.99 (d, J = 8.0 Hz, 2H), 7.82 (td, J = 8.0, 1.2 Hz, 1H), 7.50 (t, J = 8.0 Hz, 1H), 7.42-7.34 (m, 2H), 7.23-7.17 (m, 2H), 4.52 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.4, 163.8, 161.3 (d, J = 243 Hz), 141.5, 135.2, 132.7 (d, J = 4.0 Hz), 129.8 (d, J = 8.0 Hz), 127.5, 126.7, 125.5, 124.8 (d, J = 3.0 Hz), 122.7, 121.6 (d, J = 16 Hz), 115.5 (d, J = 21 Hz), 37.5. IR (KBr, cm-1): 1705, 1690. HRMS-ESI (m/z) calcd for C15H10FNO2S [M+H+] 288.0494, found 288.0495., 2634-33-5
As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.
Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica