With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61296-22-8,2-Amino-5-bromothiazole monohydrobromide,as a common compound, the synthetic route is as follows.
61296-22-8, Di-tert-butyl dicarbonate [(Boc)20, 100.7 g, 0.461 mol, 1.2 eq] was added to a flask containing a mixture of 2-amino-5-bromothiazole monohydrobromide (la?, 100 g, 0.385 mol, 1.0 eq) and 4-(dimethylamino)pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq) in900 mL of THF and 135 mL of Et3N and cooled to 0 C using an ice bath. The reaction mixture was stirred at r.t. overnight and then concentrated in vacuo. The residue was stirred in EtOAc/Heptane (1:10, 250 ml) at rt overnight and then filtered. The filtrate was washed with brine, dried, filtered, and concentrated in vacuo to furnish intermediate lb? as a yellow solid (91% yield).
As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.
Reference£º
Patent; ARIAD PHARMACEUTICALS, INC.; BENCIVENGA, Nicholas, E.; DALGARNO, David, C.; GOZGIT, Joseph, M.; HUANG, Wei-Sheng; KOHLMANN, Anna; LI, Feng; QI, Jiwei; SHAKESPEARE, William, C.; THOMAS, Ranny, M.; WANG, Yihan; ZHU, Xiaotian; (110 pag.)WO2018/112136; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica