5398-36-7,5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of ethyl 2-aminothiazole-4-carboxylate (1 g, 6.35 mmol) in acetonitrile (10 mL) and THF (10 mL) was added to a solution of t-butyl nitrite (1.3 mL, 9.52 mmol) and CUCL2 (1 g, 7.6 mmol) in acetonitrile (10 mL) and THF (10 mL) at 23 C. The reaction mixture required heating at 65 C (TLC control: 40% EtOAc-hexane) after which the mixture was cooled to room temperature, partitioned between water and ethyl acetate, the organic phase concentrated in vacuo, and purified by preparative thin layer chromatography (SIO2, 20% EtOAc-hexane) to provide the chlorothiazole ethyl ester (424 mg). This ethyl ester was converted into its carboxylic acid under typical saponification conditions known to those skilled in the art, and the latter was converted into the corresponding aldehyde as described for Intermediate 6.
The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2004/58702; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica